Award Number: W81XWH-11-1-0357 TITLE: New Treatments for Drug-Resistant Epilepsy that Target Presynaptic Transmitter Release PRINCIPAL INVESTIGATOR:

Year 1 Abnormal function and reorganization of presynaptic nanocomponents in experimental epilepsy: A multiphoton laser scanning confocal imaging and transmission electron microscopy study. Upreti C, Skinner F, Otero R, Thakker R, Rosas G, Partida C, Pacheco LF, Jones TA, Romanovicz D, Stanton PK and Garrido-Sanabria ER. 3 Meeting of the American Society for Nanomedicine, Rockville, MD, Nov 9-11, 2011. Abnormalities in presynaptic vesicle pools of mossy fiber boutons in the pilocarpine model of mesial temporal lobe epilepsy. Upreti PK, Stanton E, Garrido-Sanabria ER. Poster. 779.10/Z13 Society for Neuroscience Meeting, Washington, Nov 16, 2011. Abnormal functional and ultrastructural changes of synaptic vesicle pools at active zones in mossy fiber boutons in mesial temporal lobe epilepsy, (ID: 1149994), Upreti C, Garrido-Sanabria ER, Stanton PK, presented at the 65 America Epilepsy Society Annual Meeting, Baltimore, December 2-6, 2011. Abnormal Ultrastructure of Large Mossy Fiber Boutons-CA3 pyramidal Cell Synapses in Mesial Temporal Lobe Epilepsy. (ID: 1150094). Garrido-Sanabria ER, Otero R, Thakker R, Partida C, Skinner F, Jones T, Romanovicz D, Upreti C, Stanton PK., presented at the 65 America Epilepsy Society Annual Meeting, Baltimore, December, 2011.